Quantifying uncertainty in pulsed field ablation due to parameter diversity in conductivity models

نویسندگان

چکیده

<b>Background:</b> Pulsed field ablation (PFA) is a new type of physical energy source in the fields tumor and atrial fibrillation ablation, based on irreversible electroporation with non-thermal, clear boundaries, selective killing, rapid advantages. PFA induces changes electrical conductivity zone, which can be described by step function used to predict zone. However, current research has not compared advantages disadvantages different models, nor considered effects model parameters due individual differences errors efficacy PFA. <b>Objectives:</b> To compare two commonly models (Heaviside Gompertz model), quantify influence input uncertainty output <b>Methods:</b> This work employs quantification sensitivity analysis parameter output, clarify distribution, provide selection criteria from perspectives complexity, robustness. Combined finite element simulation, study quantifies most sensitive threshold <b>Results:</b> Different exhibit robustness when there same proportion variation parameters. The Heaviside model, determined single factor, strong jointly multiple parameters, making it susceptible various conditions. pre-treatment tissue are affecting assessment depth. Changes result Gaussian distribution greater change conductivity, depth, but nonlinear proportional relationship. <b>Conclusions:</b> approach improve accuracy reliability prediction, visual global way show uncertainties ranking, effectively reduce computational costs, optimize candidate models. strategy enhance credibility simplify mathematical physics simulation

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Quantifying uncertainty in state and parameter estimation.

Observability of state variables and parameters of a dynamical system from an observed time series is analyzed and quantified by means of the Jacobian matrix of the delay coordinates map. For each state variable and each parameter to be estimated, a measure of uncertainty is introduced depending on the current state and parameter values, which allows us to identify regions in state and paramete...

متن کامل

Quantifying uncertainty in elevation models using kriging

Raster based digital elevation models (DEM) are the basis of some of the most important GIS workflows: hydrologic modeling, site suitability, and cost path analysis. While there are several techniques for generating digital elevation models (DEMs), none of them can produce a true elevation surface. Locally varying measurement error and the inexactness of the interpolation methods contribute to ...

متن کامل

Quantifying Model Output Uncertainty Due to Spatial Variability of Rainfall'

Traditionally in the application of hydrologic/water quality (H/WQ) models, rainfall is assumed to be spatially homogeneous and is considered not to contribute to output uncertainty. The objective of this study was to assess the uncertainty induced in model outputs solely due to rainfall spatial variability. The study was conducted using the AGNPS model and the rainfall pattern captured by a ne...

متن کامل

Quantification of Uncertainty Due to Subgrid Heterogeneity in Reservoir Models

Due to the lack of data, a reservoir engineer needs to calibrate unknown petrophysical parameters based on production history. However, because the observations cannot constrain all the subsurface properties over a field, production forecasts for reservoirs are essentially uncertain. In general, many parameters of the model must be adjusted in the historymatching process, and the amount of comp...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Chinese Physics

سال: 2023

ISSN: ['1000-3290']

DOI: https://doi.org/10.7498/aps.72.20230203